Do Not Disturb follows Chloe and Jack’s honeymoon in Miami where a peyote trip to strengthen their marriage becomes a narcotic nightmare. As they confront their troubled relationship, they discover that this strand of peyote awakens a desire to consume human flesh. Their suite becomes an insatiable den of love, lust and carnal desire as Chloe comes to the realization that the only way to escape this toxic marriage is to literally consume Jack.